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KMID : 0043319930160040289
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Archives of Pharmacal Research
1993 Volume.16 No. 4 p.289 ~ p.294
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Binding of Sanjoinine-A (Frangufoline) to Calmodulin
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Han Yong-Nam
Kim Geum-Yi
Hwang Keum-Hee
Han Byung-Hoon
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Abstract
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A binding protein of radio-labeled sanjoinine-A (fangufoline) in rat brain cytoplasm was investigated, using an equilibrium dialysis technique. The labeled agent was bound to the cytosol fraction with two distinctly different types of sets in calclum ion-dependent manner. The bound protein was identified as calmodulin by dgel filtration of the sanjoinine-A bound cytosol fraction on a Sephadex G-75 column. Calmodulin was bound to sanjoinine-A bound at two sets of binding sites in the calculated as two at high affinity sites and four at low affinity sites .
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KEYWORD
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Cyclopeptide alkaloid, Frangufoline, Zizypus vulgais var, spinosus, Calmodulin binding
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